Study of circular DNA comes full circle with use of old technique

A 50-year-old lab technique is helping researchers better understand circular DNA, a lesser-known and poorly understood cousin of the linear version commonly associated with life’s genetic blueprint. With the aid of a process called density gradient centrifugation, a research team recently published a study that for the first time characterizes all of the circular DNA in the worm C. elegans, as well as in three human cell types. 

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